研究队伍 当前位置: 首页>科学研究>研究队伍
王琳
作者: 时间:2021-12-27 微信分享:
浏览量:1128

        王琳,药理学系课题组长,研究员、博士研究生导师,院校准-长聘教职引进人才。20156月毕业于浙江大学化学系,获理学博士学位。20159月进入北京工业大学从事单细胞质谱分析方向的研究。2017年加入美国普林斯顿大学从事博士后研究,并于202111月加入中国医学科学院基础医学研究所&北京协和医学院基础学院。


研究方向
        
课题组主要研究领域为代谢分析及空间代谢成像。相关成果已在NatureNature MetabolismNature MethodsCell MetabolismPANSAnalytical Chemistry等专业期刊发表论文30余篇,其中第一作者/通讯作者论文11篇,授权中国专利1项。近期课题组研究方向包括:

(1)靶向定量代谢组学及非靶向代谢分析。

(2)基于质谱成像技术的空间代谢及代谢流研究:将代谢信息由浓度扩展到代谢通量,由一维器官之间的分布扩展到二维器官内分布及三维细胞间分布,深入揭示我们的代谢变化“在哪里发生”、“如何发生”以及“如何调控”,拓展对疾病发生、发展等生物过程的认知。

(3)开展人群队列生物样本的高通量代谢组学分析:发现及鉴定新的潜在的疾病代谢物,研究其与疾病发生发展的关系及作用机理,推动质谱技术的临床化应用。

 

课题组招聘

       2022年度课题组计划在基础生物学、生物化学、生物信息学或化学方向招聘1名助理研究员(事业编制)、1名技术岗工作人员。课题组鼓励工作人员独立申请和完成科研项目。

       同时,课题组长期招收博士研究生/硕士研究生。课题组及所在研究所具有先进的质谱技术平台,与哈佛大学、普林斯顿大学、匹兹堡大学等多所学校合作紧密,可为研究生提供合理完善的培养条件。欢迎对交叉学科研究感兴趣的同学联系我们。

 

联系方式

linwang@ibms.pumc.edu.cn

北京市东城区东单三条5号可胜大楼

 

近五年代表性论文

  1. 1. Wang, L., Xing, X., Zeng, X. F., Jackson, S. R., TeSlaa, T., Wolff, J., Yang, L. F., Rabinowitz, J. D.,* Davidson, S. M.,* Spatially-resolved isotope tracing reveals tissue metabolic activityNature MethodsPre-print.
  2. 2. Chen, L., Lu, W., Wang, L., Xing, X., Chen, Z., Teng, X., Zeng, X., Muscarella, A. D., Shen, Y., Cowan, A., McReynolds, M. R., Kennedy, B. J., Lato, A. M., Campagna, S. R., Singh, M., Rabinowitz, J. D.,* Metabolite discovery through global annotation of untargeted metabolomics data. Nature Methods2021, 18, 1377-1385.
  3. 3. Ghergurovich, J. M., Xu, X., Wang, J. Z., Yang, L., Ryseck, R., Wang, L., Rabinowitz, J. D.,* Methionine synthase supports tumour tetrahydrogolate pools. Nature Metabolism2021, 3, 1512-1520.
  4. 4. Parkhitko A. A.,* Wang, L., Filine, E., Jouandin, P., Leshchiner, D., Binari, R., Asara, J. M., Rabinowitz, J. D., Perrimon, N.,* A genetic model of methionine restriction extends Drosophila health and lifespan. Proc. Natl. Acad. Sci U S A2021, 118, e2110387118.
  5. 5. TeSlaa, T., Bartman, C. R., Jankowski, C., Zhang, Z., Xu, X., Xing, X., Wang, L., Lu, W., Hui, S., Rabinowitz, J. D.,* The source of glycolytic intermediates in mammalian tissues. Cell Metabolism2021, 33, 367-378.
  6. 6. Barekatain, Y., Ackroyd, J. J., Yan, V. C., Khadka, S., Wang, L., Chen, K., Poral, A. H., Tran, T., Georgiou, D. K., Arthur, K., Lin, Y., Satani, N., Ballato, E. S., Behr, E. I., Verhaak, R., Huse, J. T., Asara, J. M., Kalluri, R., Muller, F. L.*, Nature Communications2021, 4228, DOI: 10.1038/s41467-021-24240-3.
  7. 7. Luongo, T. S., Eller, J. M., Lu, M-J., Niere, M., Raith, F., Perry, C., Bornstein, M. R., Oliphint, P., Wang, L., McReynolds, M. R., Migaud, M. E., Rabinowitz, J. D., Johnson, F. B., Johnsson K., Ziegler, M., Cambronne, X. A., Baur, J. A.,* SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature2020588, 174-179.
  8. 8. Green, R., Wang, L., Hart, S. F. M., Lu, W., Shelding, D., Burton, J. C., Mi, H., Capel, A., Chen, H. A., Lin, A., Subramaniam, A. R., Rabinowitz, J. D., Shou, W.,* Metabolic excretion associated with nutrient growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS Biology, 2020, 18, e3000757.
  9. 9. Hui, S.,* Cowan, A. J., Zeng X., Yang, L., TeSlaa, T., Li, X., Bartman, C., Zhang, Z., Jang, C., Wang, L., Lu, W., Rojas, J., Baur, J., Rabinowitz, J. D.,* Quantitative fluxomics of circulating metabolites. Cell Metabolism2020, 32, 676-688.
  10. 10. Shen, K. X., Wang, L., He, Q., Jin, Z., Chen, W. Y., Sun, C. R.,* Pan, Y. J. Sensitive bromine-labeled probe D-BPBr for simultaneous identification and quantification of chiral amino acids and amino containing metabolites profiling in human biofluid by HPLC/MS. Analytical Chemistry2020, 92, 2, 1763-1769.
  11. 11. Yang, L. F., Canaveras, J. C. G., Chen, Z. H., Wang, L., Jang, C., Morsher, R. J., Zhang, Z. Z., Ghergurovich, J. M., Su, X. Y., Mayr, J. A., Rabinowitz, J. D.,* Serine catabolism feeds NADH when respiration is impaired. Cell Metabolism, 2020, 31(4), 809-821.
  12. 12. Liu, Z., Shao, Y. L., Wang, L.,* Gas phase reaction between chromones and solvent in an electrospray ionization source. Journal of Mass Spectrometry201954, 66-72.
  13. 13. Benson, K. K., Hu, W., Weller, A. H., Chen, E. R., Khetarpal, S. A., Yoshino, S., Bone, W. P., Wang, L., Rabinowitz, J. D., Voight, B. F., Soccio, R. E.* Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene. Proc Natl Acad Sci USA2019, 116: 23232-23242.  
  14. 14. Jang, C., Hui, S., Zeng, X., Cowan, A. J., Wang, L., Chen, L., Mrscher, R. J., Reyes, J., Frezza,C., Hwang, H. Y., Imai, A., Saito, Y., Okamoto, K., Vaspoli, C., Kasprenski, L., Zsido, G. A., Gorman, J. H., Gorman, R. C., Rabinowitz, J. D.,* Metabolite exchange between mammalian organs quantified in pigs. Cell Metabolism2019, 30(3): 594-606.
  15. 15. Wang, L., Xing, X., Chen, L., Yang, L., Su, X., Rabitz, H. A., Lu, W.,* Rabinowitz, J. D.,* Peak annotation and verification engine (PAVE) for untargeted LC-MS metabolomics. Analytical Chemistry, 2018, 91(3): 1838-1846.
  16. 16. Lu, W., Wang, L., Chen, L., Hui, S., Rabinowitz, J. D.,* Extraction and quantitation of nicotinamide adenine dinucleotide redox cofactors. Antioxid Redox Signal2018, 28, 167-179.
  17. 17. Wang, L., Zhe, J., Wang, X., Zeng, S., Sun, C.,* Pan, Y.* Pair of stereodynamic chiral benzylicaldehyde probes for determination of absolute configuration of amino acid residues in peptides by mass spectrometry. Analytical Chemistry, 201789, 11902-11907.
  18. 18. Chai, Y.,* Shao, Y., Wang, L.* Loss of benzaldehyde in the fragmentation of protonated benzoylamines: benzoyl cation as a hydride acceptor in the gas phase. Journal of Mass Spectrometry201752, 664-671