葛微教授本科毕业于北京师范大学化学系，之后在河北农业大学从事教学科研工作5年。2002年，获得牛津大学全额奖学金资助攻读有机化学博士，师从Professor Sir Jack. E. Baldwin，2005年在牛津大学取得博士学位，2005-2012年在牛津大学Professor Christopher J Schofield课题组做博士后研究。2013年回国后被聘为中国医学科学院基础医学研究所免疫系教授，博士生导师，获得协和学者称号。

研究兴趣和方向

1. 结直肠癌的免疫应答分子机制的研究。

2. 基于人脑组织库的蛋白质组学研究。

Publications:

2017(10篇)    2016(9篇)  2015年(6篇)   2014年(8篇)   2013年(3篇)    2012-2008年(13篇)  【超链接】

科研和工业服务：

1. 双特异性抗体合成

2. 核素（18F, 11C, 99mTc, 188Re, 68Ga）标记小分子和抗体；

3. 特殊小分子合成定制

具体请联系方老师(电话：010-69156470)

联系方式：

办公电话：69156470

邮箱：wei.ge@chem.ox.ac.uk

办公室：老科研楼347室

2017年

(1)      Xu B, Zhao Y, Wang X, Gong P, Wei G. MZH29 is a novel potent inhibitor that overcomes drug resistance-FLT3 mutations in acute myeloid leukemia. Leukemia 2017, 31: 913-921.

(2)      Yanpan Gao, Yanyu Chen, Shaohua Zhan, Wenhao Zhang, Feng Xiong and Wei Ge. Comprehensive proteome analysis of lysosomes reveals the diverse function of macrophages in immune responses. Oncotarget, 2017, Vol. 8, (No. 5), pp: 7420-7440.

(3)      Shaohua Zhan, Tianxiao Wang, Wei Ge. Multiple functions of the E3 ubiquitin ligase CHIP in immunity. Int Rev Immunol. 2017 Jun 2:1-13.

(4)      Rachel Chun Yee Tam, Michelle Wing Man Li, Yan Pan Gao, Yuen Ting Pang, Sheng Yan, Wei Ge, Chak Sing Lau. Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research. 2017 Mar 15;352(2):304-312.

(5)      Qingzhong He, Wei Ge. The tandem Agenet domain of fragile X mental retardation protein interacts with FUS. Scientific reports, 2017, 7, 962.

(6)      Benhong Xu*, Yanpan Gao*, Shaohua Zhan and Wei Ge. Quantitative proteomic profiling for clarification of the crucial roles of lysosomes in microbial infections. Molecular Immunology. 2017, 87, 122-131.

(7)      Fuxing Zuo, Feng Xiong, Xia Wang, Xueyuan Li, Renzhi Wang, Wei Ge, Xinjie Bao. Intrastriatal Transplantation of Human Neural Stem Cells Restores the Impaired Subventricular Zone in Parkinsonian Mice. Stem Cells 2017 35 (6): 1519-1531.

(8)      Yanyu Chen, Yong Xie, Lai Xu, Shaohua Zhan, Yi Xiao, Yanpan Gao, Bin Wu, Wei Ge. Protein content and functional characteristics of serum-purified exosomes from patients with colorectal cancer revealed by quantitative proteomics. International Journal of Cancer. 2017 Feb 15;140(4):900-913.

(9)      Xia Wang, Qiang Hao, Yuanli Zhao, Yi Guo, Wei Ge. Dysregulation of cell-cell interactions in brain arteriovenous malformations: A quantitative proteomic study. Proteomics Clin Appl 2017 11(5-6).

(10)   Yong Xie, Yanyu Chen, Licheng Zhang, Wei Ge, Peifu Tang. The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodeling. J Cell Mol Med 2017, 21, 1033-1041.

2016年

(1)    Xu L, Gao Y, Chen Y, Xiao Y, He Q, Qiu H, Ge W. Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer. Oncotarget 2016, 7, 43868-43893.

(2)    Xiong Q, Zhan S, Zhang N, Ge W, Wang T: Protein progiling of papillary thyroid carcinoma with and without lymph node metastasis: a proteomic study. Int J Clin Exp Pathol 2016, 9(3):3057-3069.

(3)    Xu B, Xiong F, Tian R, Zhan S, Gao Y, Qiu W, Wang R, Ge W, Ma C: Temporal lobe in human aging: A quantitative protein profiling study of samples from Chinese Human Brain Bank. Exp Gerontol 2016, 73:31-41.

(4)    Xu B, Tian R, Wang X, Zhan S, Wang R, Guo Y, Ge W: Protein profile changes in the frontotemporal lobes in human severe traumatic brain injury. Brain Res 2016, 1642:344-52.

(5)    Xu B, Gao Y, Zhan S, Xiong F, Qiu W, Qian X, Wang T, Wang N, Zhang D, Yang Q, Wang R, Bao X, Dou W, Tian R, Meng S, Gai WP, Huang Y, Yan XX, Ge W, Ma C: Quantitative protein profiling of hippocampus during human aging. Neurobiol Aging 2016, 39:46-56.

(6)    Xiong Q, Zhang L, Zhan S, Ge W, Tang P: Investigation of proteome changes in osteoclastogenesis in low serum culture system using quantitative proteomics. Proteome Sci 2016, 14:8.

(7)    Xiong Q, Zhang L, Ge W, Tang P: The roles of interferons in osteoclasts and osteoclastogenesis. Joint Bone Spine 2016, 83(3):276-81.

(8)    Xin L, Xu B, Ma L, Hou Q, Ye M, Meng S, Ding X, Ge W: Proteomics study reveals that the dysregulation of focal adhesion and ribosome contribute to early pregnancy loss. Proteomics Clin Appl 2016, 10(5):554-563.

(9)    Xiong Q, Ge W. Gene mutations in Cushing’s disease. Biomedical Reports. 2016, 5(3):277-282.

2015年

(1)    Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X, Zhao D, Liu Y, Wang C, Zhang X, Su X, Liu J, Ge W, Levine RL, Li N, Cao X: Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6. Nature 2015, 525(7569):389-393

(2)    Yang J, Gao Y, Liu W, Ge W, Zhao R: The degradation and mineralization of acephate by ionization irradiation. Environ Prog Sustain 2015, 34(2):324-332.

(3)    Xiong Q, Zhang L, Xin L, Gao Y, Peng Y, Tang P, Ge W: Proteomic study of different culture medium serum volume fractions on RANKL-dependent RAW264.7 cells differentiating into osteoclasts. Proteome Sci 2015, 13:16.

(4)    Xiong Q, Tang P, Gao Y, Zhang L, Ge W: Proteomic Analysis of Estrogen-Mediated Signal Transduction in Osteoclasts Formation. Biomed Res Int 2015, 2015:596789.

(5)    Xie Y, Zhang L, Gao Y, Ge W, Tang P: The Multiple Roles of Microrna-223 in Regulating Bone Metabolism. Molecules 2015, 20(10):19433-19448.

(6)    Su X, Wang H, Ge W, Yang M, Hou J, Chen T, Li N, Cao X: An In Vivo Method to Identify microRNA Targets Not Predicted by Computation Algorithms: p21 Targeting by miR-92a in Cancer. Cancer Res 2015, 75(14):2875-2885.

(7)    Jin J, Xiao Y, Hu H, Zou Q, Li Y, Gao Y, Ge W, Cheng X, Sun SC: Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Commun 2015, 6:5930.

(8)    Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA: Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. Structure 2015, 23(4):639-652.

(9)    Ge W, Li D, Gao Y, Cao X: The Roles of Lysosomes in Inflammation and Autoimmune Diseases. Int Rev Immunol 2015, 34(5):415-431.

2014年

(1) Tang P, Xiong Q, Ge W, Zhang L. The role of microRNAs in osteoclasts and osteoporosis. RNA biology 2014;11: 1355-63.

(2) Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JR, Vollmar M, et al. Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature 2014;510: 422-6.

(3) Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Munzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Ge W, et al. Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Molecular cell 2014;53: 645-54.

(4) He Q, Ge W. FMRP: a new chapter with chromatin. Protein & cell 2014;5: 885-8.

(5) He Q, Zhang H, Wang Y, Ting HH, Yu W, Cao X, Ge W. Purified anti-CD3 x anti-HER2 bispecific antibody potentiates cytokine-induced killer cells of poor spontaneous cytotoxicity against breast cancer cells. Cell & bioscience 2014;4: 70.

(6) Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA,  Cockman  ME,  Kessler  BM,  Ratcliffe  PJ,  Wolf  A,  Schofield  CJ.  Hydroxylation  of  the eukaryotic  ribosomal  decoding  center  affects  translational  accuracy.  Proceedings  of  the National Academy of Sciences of the United States of America 2014;111: 4019-24.

(7) Scotti JS, Leung IK, Ge W, Bentley MA, Paps J, Kramer HB, Lee J, Aik W, Choi H, Paulsen SM, Bowman LA, Loik ND, et al. Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proceedings of the National Academy of Sciences of the United States of America 2014;111: 13331-6.

(8) Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, et al. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proceedings of the National Academy of Sciences of the United States of America 2014;111: 4031-6.

2013年

(1) Yang  M,  Hardy  AP,  Chowdhury  R,  Loik  ND,  Scotti  JS,  McCullagh  JS,  Claridge  TD, McDonough  MA,  Ge  W,  Schofield  CJ.  Substrate  selectivity  analyses  of  factor  inhibiting hypoxia-inducible factor. Angewandte Chemie (International ed in English) 2013;52: 1700-4.

(2) Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site. FEBS letters 2013;587: 2705-9.

(3) Huang L, Liu Y, Wang L, Chen R, Ge W, Lin Z, Zhang Y, Liu S, Shan Y, Lin Q, Jiang M. Down-regulation    of    miR-301a    suppresses    pro-inflammatory    cytokines    in    Toll-like receptor-triggered macrophages. Immunology 2013;140: 314-22.

2012-2008年

(1) Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen  binding and  a link to nitrile  hydratase?  Journal of  the American Chemical Society 2008;130: 10096-102.

(2) Ge W, Clifton IJ, Howard-Jones AR, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide  substrate  analogue. Chembiochem :  a  European journal of  chemical biology 2009;10: 2025-31.

(3) Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Lienard BM, Schofield CJ, Clifton IJ. Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorganic & medicinal chemistry letters 2010;20: 6125-8.

(4) Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase. Biochemical and biophysical research communications 2010;398: 659-64.

(5) Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase. Organic & biomolecular chemistry 2010;8: 122-7.

(6) Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8,  a  gene  associated  with  cleft  lip/palate  and  mental  retardation,  encodes  for  an Nepsilon-dimethyl lysine demethylase. Human molecular genetics 2010;19: 217-22.

(7) Yue  WW,  Hozjan  V,  Ge  W,  Loenarz  C,  Cooper  CD,  Schofield  CJ,  Kavanagh  KL, Oppermann   U,   McDonough   MA.   Crystal   structure   of   the   PHF8   Jumonji   domain,   an Nepsilon-methyl lysine demethylase. FEBS letters 2010;584: 825-30.

(8) Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. The crystal structure of isopenicillin  N  synthase  with  delta-((L)-alpha-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron. Archives of biochemistry and biophysics 2011;516: 103-7.

(9) Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. Isopenicillin N synthase binds delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms. Chembiochem : a European journal of chemical biology 2011;12: 1881-5.

(10) Yang M, Chowdhury R, Ge W, Hamed RB, McDonough MA, Claridge TD, Kessler BM, Cockman ME, Ratcliffe  PJ,  Schofield  CJ.  Factor-inhibiting  hypoxia-inducible  factor  (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. The FEBS journal 2011;278: 1086-97.

(11) Yang M, Ge W, Chowdhury R, Claridge TD, Kramer HB, Schmierer B, McDonough MA, Gong L, Kessler BM, Ratcliffe PJ, Coleman ML, Schofield CJ. Asparagine and aspartate hydroxylation of the cytoskeletal Ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. The Journal of biological chemistry 2011;286: 7648-60.

(12) Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature chemical biology 2012;8: 960-2.

(13) Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, et al. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angewandte Chemie (International ed in English) 2012;51: 1631-4.

王霞 助理研究员

王霞博士毕业于北京师范大学化学系，2010-2015年就读于无机化学专业放射性药物化学领域刘伯里院士课题组，师从贾红梅教授，2015年6月获理学博士学位。博士期间，获得博士研究生国家奖学金和北京师范大学一等奖学金。2013年，获国际原子能机构（NIH）资助参加“the 20^th international Radiophamaceutical Sciences”作大会口头报告。研究生期间的研究方向：以sigma受体为靶点，研制新型有机小分子放射性药物，对中枢神经系统疾病（如抑郁，焦虑，早老性痴呆，记忆力减退等）和肿瘤（乳腺癌，前列腺癌等）进行早期诊断。研究内容包括有机小分子药物制备，放射性药物（核素药物）制备，及放射性药物在细胞及小鼠体内的评价。博士期间以第一作者发表SCI学术论文2篇，其中一篇发表在药物化学领域顶尖级期刊Journal of Medicinal Chemistry上。

研究兴趣和方向：

1.       中枢神经系统疾病（AVM, PD, AD）的早期诊断及发病机制的研究

2.       小分子药物对中枢神经系统疾病的干预

Publications:

2017年（2篇）  2016年（1篇）  2014年（2篇）  2013年（2篇）   2012年（1篇）   (超链接)

联系方式：

邮箱：wangxia1507@gmail.com

手机：15117924226

（链接）

2017年

(1)    Xia Wang, Qiang Hao, Yuanli Zhao, Yi Guo, Wei Ge. Dysregulation of cell-cell interactions in brain arteriovenous malformations: A quantitative proteomic study. Proteomics Clin Appl 2017 11(5-6).

(2)    Fuxing Zuo^#, Feng Xiong^#, Xia Wang^#, Xueyuan Li, Renzhi Wang, Wei Ge, Xinjie Bao. Intrastriatal Transplantation of Human Neural Stem Cells Restores the Impaired Subventricular Zone in Parkinsonian Mice. Stem Cells 2017 35 (6): 1519-1531.

2016年

(1)    Xu B, Tian R, Wang X, Zhan S, Wang R, Guo Y, Ge W: Protein profile changes in the frontotemporal lobes in human severe traumatic brain injury. Brain Res 2016, 1642:344-52.

2014年

(1)    Wang X, Li D, Deuther-Conrad W, Lu J, Xie Y, Jia B, Cui M, Steinbach J, Brust P, Liu B, Jia H. Novel cyclopentadienyl tricarbonyl (99m)tc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors. J Med Chem. 2014, 57, 7113-7125

(2) Chen YY, Wang X, Zhang JM, Deuther-Conrad W, Zhang XJ, Huang Y, Li Y, Ye JJ, Cui MC, Steinbach J, Brust P, Liu BL, Jia HM. Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising σ1 receptor imaging agent. Bioorg Med Chem. 2014, 22, 5270-5278.

2013年

(1) Wang X, Li Y, Deuther-Conrad W, Xie F, Chen X, Cui MC, Zhang XJ, Zhang JM, Steinbach J, Brust P, Liu BL, Jia HM. Synthesis and biological evaluation of ¹⁸F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging. Bioorg Med Chem. 2013, 21, 215-222

(2) Li Y, Wang X, Zhang J, Deuther-Conrad W, Xie F, Zhang X, Liu J, Qiao J, Cui M, Steinbach J, Brust P, Liu B, Jia H. Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives as σ₁ receptor ligands for positron emission tomography imaging. J Med Chem. 2013, 56, 3478-3491.

2012年

(1) Chen X, Cui MC, Deuther-Conrad W, Tu YF, Ma T, Xie Y, Jia B, Li Y, Xie F, Wang X, Steinbach J, Brust P, Liu BL, Jia HM. Synthesis and biological evaluation of a novel 99mTc cyclopentadienyl tricarbonyl complex ([(Cp-R)^99mTc(CO)₃]) for sigma-2 receptor tumor imaging. Bioorg Med Chem Lett. 2012, 22, 6352-6357.

组内人员

研究助理： 王 霞

联系方式：15117924226

秘    书：方  虓

联系方式：13051168676

博 士 后：熊  峰

在读学生： 高延盼（博士生）

           陈彦宇（博士生）

           占少华（博士生）

           罗  丹（博士生）

           张雨生（博士生）

           夏文超（硕士生）

已毕业学生：何庆仲（博士），许本洪（博士）

照片

2017年

2015年

2013年