杜文静课题组

杜文静，女，博士。

2016年1月起，在细胞生物学系成立课题组,并任课题组长,隶属医学分子生物学国家重点实验室。

课题组研究方向：

本课题组的研究兴趣是肿瘤代谢。与正常的细胞相比，肿瘤细胞为了满足其快速生长的需求，其能量代谢途径通常会发生异常改变。 本实验室主要利用细胞、生化、分子生物学手段和小鼠模型来探索肿瘤细胞中发生异常改变的代谢途径，研究代谢异常改变的分子调控机制，通过研究希望能为癌症的治疗提供新的思路，为抗癌药物的设计提供新靶点。

课题组成员:

助理研究员:李莉

实验室管理员:李薇

学生:孙会珊,寇俊婕,赵丹,陈勇

联系方式：

中国医学科学院基础医学研究所，细胞生物学系，老科研楼457

北京市东城区东单三条5号，邮编：100005

电话：010-69156953

Email: wenjingdu@ibms.pumc.edu.cn;  wjdu123@hotmail.com

代表性研究论文：

1.    Yao P, Sun H, Xu C, Chen T, Zou B, Jiang P, Du W(杜文静). Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions. 

J Biol Chem. (2017), Oct 13;292(41):17113-17120.

2.   Jiang P, Du W(杜文静) and Mian Wu. Regulation of the pentose phosphate pathway in cancer. 

Protein&Cell. (2014), Aug,5(8):592-602.

3.   Jiang P,Du W(杜文静) and Yang X. Critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation. Cell Cycle. (2013), Dec 15; 12(24): 3720-6.

4.   Jiang P,Du W(杜文静) and Yang X. p53 and regulation of tumor metabolism. Journal of Carcinogenesis. (2013), Nov 6; 12:21.

5.    Du W*(杜文静), Jiang P*,Mancuso A,StonestromA, BrewerM, Minn AJ, MakTW, Wu M and YangX. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology.(2013), Aug. 15, 991–1000.该论文为封面提名文章，同期伴有国际同行专家的长篇评论。

6.    Jiang P*,Du W*(杜文静), Mancuso A, Wellen KE, Yang X. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. (2013), Jan. 493: 689-693.

7.    Jiang P*,Du W*(杜文静), WangX, MancusoA, GaoX, Wu Mand YangX. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.Nature Cell Biology. (2011) Mar.13: 310-316. 该论文为封面提名文章，同期伴有国际同行专家的长篇评论。被Nature Chemical Biology作为研究热点进行点评。

8.   Du W*(杜文静), Jiang P*,Li N, Mei Y, Wang X,WenL, Yang X and Wu M. Suppression of p53 activity by Siva1. Cell Death & Differentiation.(2009) 16: 1493-1504.

9.   Jiang P*,Du W*(杜文静), Klaus H and Wu M. The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis. Molecular and Cellular Biology.(2006) 26: 9071-9082.

10.   Jiang P, Du W(杜文静) and Wu M. p53 and Bad: remote strangers become close friends. Cell Research. (2007) 17: 283-285.

11.   Wang X, Zha M, Zhao X, Jiang P, Du W(杜文静), Tam AYH, Mei Y and Wu M. Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase. Nature Communications.(2013) 4:1551.

12.   Li N, Jiang P, Du W(杜文静), Wu Z, Li C, Qiao M, Yang X and Wu M. Siva1 inhibits epithelial–mesenchymal transition and metastasis of tumor cells. Proceedings of the National Academy of Sciences. (2011) 108: 12851-12856.

13.   Wu J, Yang Y, Zhang J, Ji P, Du W(杜文静), Jiang P, Xie D, Huang H, Wu M, Zhang G, Wu J, Shi Y. Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins.J Biological Chemistry. (2007) 282:35988-99.

14.   Ma L, Huang Y, Song Z, Feng S, Tian X, Du W(杜文静), Qiu X, Heese K, Wu M. Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway.Cell Death Differentiation. (2006) 13:2079-88.

15.   Mei Y, Du W(杜文静), Yang Y, Wu M. Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1.Oncogene. (2005) 24:7224-37.